Identification of Hodgkin and Reed-Sternberg Cell-Specific Genes by Gene Expression Profiling

Küppers, R., U. Klein, I. Schwering, V. Distler, A. Bräuninger, G. Cattoretti, Y. Tu, G.A. Stolovitzky, A. Califano, M.-L. Hansmann, and R. Dalla-Favera.

J. Clin. Invest. 111:529-537, 2003

This webside contains the primary Affymetrix U95A gene chip hybridization data used in the above analysis in two forms:

1.)  Affymetrix CEL files.

2.)    The “average differences” / “signals” and the A, M or P calls of the respective samples as obtained by analyzing CEL files using Microsoft Analysis Suite (MAS) 5.0 with standard parameters and TGT=2,500. Of note, the “average differences” used for the analysis described in the present manuscript were obtained with MAS4.0 (TGT=2,500); we here chose to deposit primary data analyzed with MAS5.0 to allow future comparisons. The respective “signals” of the probe sets are ordered as in the Affymetrix CHP file; of note, the “spike control” probe set values are omitted.

The primary data of the four Hodgkin cell lines and the four normal B-cell subset (5 CB, 5 CC, 5 naïve, and 5 memory B-cell samples) correspond to those used in: Schwering et al. 2003. Loss of B-cell specific gene expression program in Hodgkin and Reed/Sternberg cells of Hodgkin’s lymphoma. Blood 101:1505-1512.

Source	Format	Size	Download
B-CLL biopsies	ZIP	33 MB
BL biopsies	ZIP	13 MB
BL cell lines	ZIP	23 MB
DLCL biopsies	ZIP	23 MB
DLCL cell lines	ZIP	27 MB
FL biopsies	ZIP	20 MB
HD cell lines	ZIP	13 MB
Normal B-cells	ZIP	67 MB
LCL	ZIP	17 MB
All Data - EXCEL table	ZIP	8 MB