Dr. Tycko’s lab is pursuing several different lines of research: 1) the epigenetics and genetics of Wilms tumors and other human cancers; 2) the identities and the physiological functions of imprinted genes; 3) the genetic basis for phenotypes in Down syndrome. His lab also collaborates with others at Columbia to study the population genetics of Alzheimer’s disease. Selected publications are listed below.

 

 

Selected Publications

Yuan E, Haghighi F, White S, Costa R, Chun K, McMinn J, Minden M, Tycko B (2006) A SNP chip method (MSNP) for combined genetic and epigenetic profiling: validation in Decitabine therapy and tumor/normal comparisons. Cancer Res 66, 3443-3451.

Moulton T, Crenshaw T, Hao Y, Moosikasuwan J, Lin N, Dembitzer F, Hensle T, Weiss L, McMorrow L, Loew T, Kraus W, Gerald W, Tycko B (1994) Epigenetic lesions at the H19 locus in Wilms’ tumor patients. Nature Genet 7, 440-447.

Li C-M, Guo M, Borczuk A, Powell CA, Wei M, Thaker HM, Friedman R, Klein U, Tycko B (2002) Gene expression in Wilms tumors mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition. Am J Pathol, 160, 2181-2190. Supplementary Data.

 Li C-M, Kim CE, Margolin AA, Guo M, Zhu J, Mason JM, Hensle TW, Murty VVS, Grundy PE, Fearon ER, D’Agati V, Licht JD, Tycko B (2004) CTNNB1 mutations and over-expression of Wnt/beta-catenin target genes in WT1-mutant Wilms tumors. Am J Pathol, 165, 1943-1953.

Frank D, Fortino W, Clark L, Musalo R, Wang W, Saxena A, Li C-M, Reik W, Ludwig T, Tycko B. (2002) Placental overgrowth in mice lacking the imprinted gene Ipl. Proc Natl Acad Sci, 99, 7490-7495.

Salas M, John R, Saxena A, Barton S, Frank D, Fitzpatrick G, Higgins M, Tycko B (2004) Placental growth retardation due to loss of imprinting of Phlda2. Mech Development, 121, 1199-210.