Time: October 27 to October 31, 2008.

Location: Fudan University Crowne Plaza, Shanghai, China.

Agenda for the 14^th International p53 Workshop

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(Welcome 欢迎) 

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Sunday, 10/26/08       Arrival, Check-in at Hotels, and Free Exploration of Shanghai

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Monday 10/27/08

7:00-9:00AM               Breakfast at Attendees’ Own Hotels

Day time                     Free Exploration of Shanghai and Dining on Your Own

2:00PM                       Registration Starts at 2pm at Crowne Plaza Hotel at Fudan, Shanghai

 

7:30-9:30PM                                                   Session 1

Crowne Plaza Second Floor Meeting Room                 Keynote Talks

7:30-7:45PM               Welcome Address from Fudan University

7:45-8:00PM               Logistics by the Organizers (Wei Gu and Hua Lu)

8:00-8:45PM               A. J. Levine Single Nucleotide Polymorphisms in the p53 Pathway (S1)

8:45-9:30PM               D. P. Lane Activating p53 Pathway from Fish to Man (S2) 

9:30-Midnight              Social Time

                                                 ********************************************************************

Tuesday 10/28/08

7:00-8:30AM               Breakfast at Attendees’ Own Hotels

 

8:30-10:05AM                                                 Session 2

Crowne Plaza Second Floor Meeting Room     Transcriptional Regulation of p53

                                                     (Chairs: Robert Roeder and Carol Prives)

8:30-8:55AM               R. Roeder Function of Diverse Cofactors in Transcriptional Activation

                                    by p53 (S3)

8:55-9:20AM               C. Prives Regulation of p53 by MDM2 and MDMX (S4)

9:20-9:45AM               C. Harris Telomeres “Coming up Short”: p53-dependent Senescence   

                                    (S5)

9:45-10:05AM             Y. Taya Novel Functions of p53 at Nucleus and Near Plasma

                                    Membrane (S6)

10:05-10:20AM           Coffee Break

 

10:20-12:00AM                                               Session 3

Crowne Plaza Second Floor Meeting Room p53 Structure and Function I

                                                    (Chairs: Alan Fersht and Michael Resnick)      

10:20-10:45AM           A. Fersht Target Mutant Rescue (S7)

10:45-11:10AM           M. Resnick The Expanding p53 Universe (S8)

11:10-11:30AM           G.P. Zambetti Regulating Nuclear Import by p53 through E124/PIG8    

                                   (S9)

11:30-11:45AM           L. Mayo The PTEN/p53/MASPIN Network to Suppress Angiogenesis

                                   (S10)

11:45-12:00PM           Z. Xiao IGF-1 Induces Premature Cellular Senescence via p53

                                    Activation (S11)

 

12:00-2:00PM             Lunch and Poster Session I at Crowne Plaza

 

2:00-3:40PM                                                   Session 4

Crowne Plaza Second Floor Meeting Room       p53 Structure and Function II

                                                     (Chairs: Wafik El-Deiry and Xinbin Chen)

2:00-2:25PM               W. El-Deiry Targeting Mutant p53 in Cancer Stem Cells (S12)

2:25-2:45PM               X. Chen Identification of ID2 as a Mutant p53-specifc Target Gene

                                    and Establishment of a Dog Model for the p53 Pathway  (S13)

2:45-3:05PM               J. Manfredi p53 Regulates Mitotic Entry and Progression via Effects

                                    on Transcription and Protein Stability of Specific Targets (S14)

3:05-3:25PM               S. Lee Identification of p53 Activators with Potent Anti-tumor Activities

                                   (S15)

3:25-3:40PM               W. Hu p53 Regulates Maternal Reproduction through Leukemia

                                    Inhibitory Factor (S16)

3:40-3:55PM               Coffee Break

 

3:55-6:05PM                                                   Session 5  

Crowne Plaza Second Floor Meeting Room   p53 Regulation: Mdm2, Mdmx and Others

                                                              (Chairs: Moshe Oren and Hua Lu)

3:55-4:20PM               M. Oren Inhibitory Interactions between MDM2 and Ribosomal

                                    Protein L26 Regulate p53 Synthesis and Stability (S17)

4:20-4:40PM               H. Lu Activation of p53 via Suppression of MDM2 and MDMX (S18)

4:40-5:00PM               A. Jochemsen Functions and Regulation of MDMX            (S19)

5:00-5:20PM               J. Chen ATM Inhibition of MDM2 Oligomerization and p53 Poly-

                                    ubiquitylation Is Essential for p53 Activation after DNA Damge (S20)

5:20-5:35PM               Z.M. Yuan  Investigation of the MDM2 Acidic Domain for Its Role in

                                    p53 Ubiquitination (S21)

5:35-5:50PM               S.C. Lin Axin Is Critical Determinant for Decision between Death and

                                    Life upon DNA Damage (S22)          

5:50-6:05PM               W.G. Zhu p53 Interacts with NUMB to Inhibit Proliferation of Colon

                                    Cancer Cells (S23)

6:05-7:30PM               Dinner at Crowne Plaza First Floor Cafeteria

 

7:30-9:45PM                                                   Session 6

Crowne Plaza Second Floor Meeting Room   p53 Regulation: Protein Modifications

                                                          (Chairs: Wei Gu and David Meek)

7:30-7:55PM               W. Gu p53 Regulation via Acetylation and Ubiquitylation (S24)

7:55-8:15PM               D. Meek p53-mediated Down-regulation of PLK1 Expression as Part

                                    of the G2/M Checkpoint to DNA Damage (S25)

8:15-8:35PM               S. Grossman Sibling Rivalry: Differential Regulation of p53 by p300

                                    and CBP (S26)

8:35-8:55PM               E. Appella Synthesis and Activity of Selective Inhibitors of WIP1, a

                                    Phosphatase that Controls p53 Pathways (S27)

8:55-9:15PM               S. Shieh Stress-induced Signaling Pathways Connecting

                                    TTK/hMPS1, ChK2 and p53 (S28)

9:15-9:30PM               N. Barlev Transcrtiptional Regulation of micro-RNAs by p53 Defines

                                    the Outcome of Genotoxic Stress (S29)

9:30-9:45PM               Z.K. Lou DBC1 Negatively Regulates Sirt1 and Potentiates p53

                                    Activity            (S30) 

                                                ********************************************************************     

Wednesday 10/29/08

7:00-8:30AM               Breakfast at Attendees’ Own Hotels

 

8:30-10:15AM                                                 Session 7      

Crowne Plaza Second Floor Meeting Room Regulation of Cell Survival, Death and Others

                                                          (Chairs: Douglas Green and Yanping Zhang)

8:30-8:55AM               D. Green p53, PUMA, and Bcl2 Family Interactions: Covert Direct

                                    Activator BH3-only Protein Function Is Revealed by PUMA-mediated

                                    De-repression (S31)

8:55-9:20AM               Y.P. Zhang Function and Mechanism of ARF in the Mitochondria  

                                   (S32)

9:20-9:40AM               M. Murphy The ARF Tumor Suppressor Confers Survival in

                                    Response to Metabolic Stress (S33)

9:40-10:00AM             Z. Dong Interaction of p53 and Histone H3 via Different Protein

                                    Kinases (S34)

10:00-10:15AM           L. Zhang  PUMA as an Essntial Mediator in p53-dependent and

                                    Independent Apoptosis (S35)                        

10:15-10:30AM           Coffee Break

 

10:30-12:05PM                                               Session 8

Crowne Plaza Second Floor Meeting Room      In Vivo Function  (I)

                                                     (Chairs: Scott Lowe and Xin Lu)

10:30-10:55AM           S. Lowe p53-mediated Senescence of Activated Stellate Cells Limits

                                    Liver Fibrosis (S36)

10:55-11:20AM           G. I. Evan p53 and Tumor Suppression--the How, the When and the

                                    Why (S37)

11:20-11:45AM           X. Lu p53: a Heavily Dictated “Dictator” of Life and Death (S38)

11:45-12:05PM           T. Tlsty Telomere Malfunction Acts through Paracrine Signaling to

                                    Condition Adjacent Cells to either Promote or Suppress Malignant

                                    Phenotypes (S39) 

 

12:05-2:00PM             Lunch and Poster Session II at Crowne Plaza

 

2:00-4:25PM                                                   Session 9      

Crowne Plaza Second Floor Meeting Room    In Vivo Function (II)

                                                (Chairs: Gigi Lozano and Geoff Wahl)

2:00-2:25PM               G. Lozano Mutant p53 Gain-of-function activities (S40)

2:25-2:50PM               T. Mak The Role of TAp73 and DNp73 in Tumor Development (S41)

2:50-3:15PM               G. Wahl Unleasing the Guardian: Developing More Effective p53

                                    Activating Therapies by Targeting MDM2 and MDMX, Its Two

                                    Negative Regulators (S42)

3:15-3:35PM               Y. Xu Genetic Analysis of p53 in Aging (S43)

3:35-3:55PM               L. Attardi Using Transactivation Domain Mutant Knock-in Mice to

                                    Define p53’s Mechanism of Action (S44)

3:55-4:10PM               S. Chang Telomere Dysfunction Suppresses Tumorigenesis in Vivo

                                    by Initiating p53-dependent Cellular Senescence (S45)

4:10-4:25PM               U Rodeck Distinct and Interdependent Functional Roles of N-

                                    Terminal p53 Variants in Zebrafish Development (S46)                   

4:30PM                       Bus to a Restaurant

5:30-7:00PM               Dinner

7:00-8:00PM               Bus to the Huang Pu River Port

8:00-9:00PM               Boat Tour on Huang Pu River in the Center of Shanghai City.

9:00-10:00PM             Return to Hotels                     

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Thursday 10/30/08

7:00-8:30AM               Breakfast at Attendees’ Own Hotels

 

8:30-10:10AM                                                 Session 10

Crowne Plaza Second Floor Meeting Room            p53 Targets

                                                      (Chairs: Varda Rotter and Karen Vousden)

8:30-8:55AM               K. Vousden A Role for the p53 Tumor Suppressor Protein in

                                    Metabolism (S47)

8:55-9:20AM               V. Rotter Identification and Characterization of p53-associated “Gene

                                    Signatures” Involved in Cellular Transformation (S48)

9:20-9:40 AM              S. Benchimol LPIN1, a Novel p53-regulated Gene Induced in

                                    Response to Metabolic Stress and DNA Damage (S49)

9:40-9:55 AM              S. Berberich YPEL3, a Novel p53 Regulated Gene with

                                    Growth Suppressive Activity (S50)

9:55-10:10AM             A. Budanov The p53-regulated Sestrin Gene Products Inhibit mTOR

                                    Signaling (S51)

10:10-10:25AM           Coffee Break

 

10:25-12:00PM                                               Session 11

Crowne Plaza Second Floor Meeting Room p53 in the Clinic and Models

                                                                    (Chair: Lin Wu)

10:25-10:50AM           L. Wu Detection of p53 Mutations in Cancer by the AmpliChip p53

                                    Test, a Microarray-based Resequencing Assay (S52)

10:50-11:10AM           F. Bunz New Isogenic Models to Discover p53-dependent

                                    Therapeutics (S53)

11:10-11:30AM           J.C. Bourdon Human p53 Isoforms and Cancer (S54)

11:30-11:45AM           K.H. Young Structural Profiles of TP53 Gene Mutations Predict

                                    Clinical Outcomes Lymphoma: An International Collaborative Study  

                                   (S55)

11:45-12:00AM          Steve Yu A New Resource to Provide a Full Spectrum of Human

p53 Point Mutations in Humanized Mouse Models (S56)

 

12:00-2:00PM             Lunch and Poster Session III at Crowne Plaza

 

2:00-4:50PM                                                  Session 12    

                                                               p63, p73 and Others

                                                (Chairs: Frank McKeon and Ute Moll)

2:00-2:25PM               F. McKeon p63: Dual Roles in Female Germline Superiority and

                                    Epithelial “Stemness” (S57)

2:25-2:50PM               U. Moll  Tumor Suppressor Properties of p73 in T- and B-cell

                                    Lymphomas (S58)

2:50-3:10PM               G. Melino p63, miRNA, “Stemness” and Skin (S59)

3:10-3:25PM               E. Flores TAp63 is a Key Regulator of Wound Repair,

                                    Stem Cell Maintenance, and Tumor Suppression (S60)

3:25-3:40PM               Coffee Break

3:40-3:55PM               Y. Haupt  Regulation of the p53 Activator PML (S61)

3:55-4:10PM               Y. Yin A Network of p53 and E2F-1 in Controlling Cellular Response

                                    to Oxidative Stress (S62)

4:10-4:30PM               F.C. He PACT is  a Negative Regulator of p53 and Essential for Cell

                                    Growth and Embryonic Development (S63)

4:30-4:50PM               A. Braithwaite The Polyproline Domain of p53 Is Required for

                                    Apoptosis and for Prevention Function of B Cell Lymphoma (S64)

5:00-6:00PM               Bus to Banquet

6:30-12:00AM             Banquet with Live Music

                                    ********************************************************************

Friday 10/31/08

7:00-8:30AM               Breakfast at Attendees’ Own Hotels

 

8:30-11:05PM                                                 Session 13

Crowne Plaza Second Floor Meeting Room        Cancer Therapy

                                                 (Chairs: Lubo Vassilev and Shaomeng Wang)

8:30-8:55AM               L. Vassilev Nultins: p53 Research Tools and Potential Therapeutics  

                                   (S65)

8:55-9:15AM               S.M. Wang Small-molecule Approach to Reactivate p53 by Blocking

                                    the MDM2-p53 Interaction as a New Cancer Therapeutic Approach:

                                    Progress and Challenges  (S66)

9:15-9:35AM               Y. Sun  A Class of Small Molecules that Promote p53 Degradation

                                   (S67)

9:35-9:50AM               G. Selivanova Molecular Mechanisms of Preferential Induction of

                                    Apoptosis by Pharmacological Reactivation of p53 (S68)

9:50-10:05AM             Coffee Break

10:05-10:20AM           K.G. Wiman   Mutant p53 Targeting by Prima-1:

                                    From Drug Discovery to Clinical Trials (S69)

10:20-10:35AM           C. Maki  Transient Nutlin-3a Treatment Promotes Endoreduplication

                                    and the Generation of Therapy-resistant Tetraploid Cells (S70)

10:35-10:50AM           M. Laiho Identification of Novel p53 Pathway Activating Small

                                    Molecule Compounds (S71)

10:50-11:05Am           S. Lain Discovery of Small Molecule Sirtuin Inhibitors Through a p53

                                    Activation Assay (S72)          

 

                                                                        Closing Session

11:05-11:45AM           Special Lecture by A.J. Levine: 30 Years of p53 Research

11:45-12:00PM           Final Logistics: Wei Gu and Hua Lu

12:00PM                     Lunch at Crowne First Floor Cafeteria

 

                                                                        Good-bye (再见)