Available Positions

1. Post-Doctoral Position in 
Columbia University Medical Center
New York City, New York, USA

labApplication is invited for a full time post-doctoral scientist position in the Zha lab within the Institute for Cancer Genetics of Columbia University. Our laboratory is interested in molecular mechanism of DNA double stand break repair and DNA damage responses in the context of lymphocyte development and cancer biology. The particular research projects will focus on 1) newly identified structural function of DNA repair proteins or 2) the functional interaction between DNA damage responses genes (e.g. ATM) and DNA repair factors and apply a multidisciplinary approach combining mouse genetics, high-throughput sequencing, cell biology, molecular biology and animal models in order to understand the role of DNA repair in human diseases. We are seeking highly motivated, ambitious, and talented scientists to join our enthusiastic and collaborative team in an outstanding scientific environment.

Starting date

This position is available from the 1st of Jan 2016 (negotiable) and interview could be arranged ASAP.

We are looking for candidates with a PhD or MD/PhD early in their academic career (within the first 2 years of graduation) with a background in DNA repair or cancer biology or immunology. Experience with high throughput sequencing analyses, mouse tumor models or multi-color FACS analyses is of advantage, but not required. Excellent English written and verbal communication skills, a high degree of motivation and organization and record of scientific accomplishments (e.g. publication track record) with manuscripts in peer-reviewed journals are a prerequisite for this position.

Research Environment
The Institute for Cancer Genetics is the basic research unit of the only NCI-designated comprehensive cancer centers at Columbia University Medical Center. Our lab is 6 years old with 8 current members including 3 post-doctoral fellow and 3 Ph.D students. We are also part of a broad network of research laboratories in New York City dedicated to DNA dynamics and genomic integrity, constituting a vibrant and collaborative environment for research.

Application process

Please submit following information in one PDF file via Email to Dr. Shan Zha at sz2296@columbia.edu

• Cover letter with detailed statement of research interests and experience (not more than 1-2 pages)
• Curriculum vitae including the complete publication list
• Three (3) letters of recommendation or the detailed contact information of three referees

2. Postdoctoral Research Scientist/Fellow Positions

Postdoctoral positions are available to study mechanisms of epigenetic inheritance and cancer epigenetics at Columbia University’s Institute for Cancer Genetics. Candidates who have a solid background in molecular biology and biochemistry and are highly self-motivated in research are encouraged to apply. Experiences in yeast, mouse embryonic stem cells and human cancer cells are preferred for these positions.

Please submit your CV and the names of three references to Dr. Zhang at zz2401@cumc.columbia.edu

Research Interest

Our first long-term goal is to determine how epigenetically determined chromatin states are inherited during S phase of the cell cycle. Towards this goal, we have been using the budding yeast, mammalian cell culture and mouse as models to address this fundamental, but poorly understood process.  Our second long-term goal is to elucidate how epigenetic alterations contribute to tumorigenesis. We are focusing on analyzing how histone variant H3.3 mutations frequently found in pediatric brain and bone tumors reprogram epigenetic landscape and drive tumorigenesis. Please visit our web at ICG for details for our research.