Available Positions


1. Postdoctoral Research Scientist/Fellow Positions

Postdoctoral positions are available to study mechanisms of epigenetic inheritance and cancer epigenetics at Columbia University’s Institute for Cancer Genetics. Candidates who have a solid background in molecular biology and biochemistry and are highly self-motivated in research are encouraged to apply. Experiences in yeast, mouse and human cancer cells are preferred for these positions.

Interested candidates email their CV and the names of three references to zz2401@cumc.columbia.edu.

Research Interest

Our first long-term goal is to determine how epigenetically determined chromatin states are inherited during S phase of the cell cycle. Towards this goal, we have been using the budding yeast, mammalian cell culture and mouse as models to address this fundamental, but poorly understood process.  Our second long-term goal is to elucidate how epigenetic alterations contribute to tumorigenesis using brain tumors as models. Detailed info about our lab can be found online at https://icg.cpmc.columbia.edu/research-faculty/Zhiguo-Zhang

Selected Publications

  1. Fang* D, Gan* H, Lee* J, Han* J, Wang* Z, Riester SM, Jin L, Chen J, Zhou H, Wang J, Zhang H, Yang N, Bradley EW, Ho TH, Rubin BP, Bridge JA, Thibodeau SN, Ordog T, Chen Y, van Wijnen AJ, Oliveira AM, Xu R, Westendorf JJ, Zhang Z (2016) The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas. Science, 352: 1344-1348.
  2. Gan H, Yu C, Devbhandari S, Sharma S, Han J, Chabes A, Remus D and Zhang Z. Checkpoint kinase Rad53 couples leading and lagging strand DNA synthesis under replication stress. Mol Cell (2017), 68, 446-455.
  3. Zhang H, Gan H, Wang Z, Lee JH, Ordog T, Wold M, Ljungman M and Zhang Z. RPA interacts with HIRA and regulates H3.3 deposition at gene regulatory elements in mammalian cells. Mol Cell (2017), 65: 272-284.
  4. Han, J, Zhang H, Zhang, H, Wang, Z, Zhou, H, Zhang Z (2013). A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly. Cell 155, 817-829.

Minimum Qualifications

Eligible candidates must have an MD and/or PHD doctoral degree in one of the following:  Biochemistry, Molecular Biology, Genetic or Cancer Biology.  Strong competence in yeast, mouse ES cells and human cancer cells; a record of productive and collaborative research; excellent communication skills in written and spoken English is required.

Please see this link for details:   https://jobs.sciencecareers.org/job/474452/postdoctoral-research-scientist-fellow-positions/

Columbia University is an Equal Opportunity/Affirmative Action employer - Race/Gender/Disability/Veteran.

2. Postdoctoral Research Scientist Position

A post-doctoral position is available in the lab of Dr. Christine Chio at Columbia University’s, Institute for Cancer Genetics to study the etiology and progression of pancreatic ductal adenocarcinoma using ex-vivo organoid cultures and in vivo genetically engineered mouse models. The lab’s research interest is investigating the role of reactive oxygen species as selective secondary messengers to support cancer cell viability and tumor-stroma co-evolution.

Position Highlights: 

  • A highly supportive and friendly lab environment.
  • Opportunity to collaborate with chemists and clinical oncologists
  • Opportunity to gain experience in both basic mechanism study and drug discovery.

The Ideal Candidate:

  • Experience with mouse genetics, metabolism and redox biology will be desirable.
  • Familiar with routine cell culture and molecular biology techniques

Credentials and Qualifications: 

  • Recent Ph.D. or M.D. graduate with a strong background in cell biology, biochemistry, molecular biology;

A competitive salary and benefits package will be offered to the successful candidate.

Interested applicants should send a single PDF file that includes current CV with recent publications, personal statement of scientific interests and goals (2-page maximum) and contact information for three references to Dr. Christine Chio at ic2445@cumc.columbia.edu and apply online at academicjobs.columbia.edu/applicants/Central?quickFind=65705

Dr. Christine Chio, PhD
Institute of Cancer Genetics
Herbert Irving Comprehensive Cancer Center
Columbia University Medical Center
New York, NY 10032

Columbia University is an Equal Opportunity/Affirmative Action employer - Race/Gender/Disability/Veteran