Dr. Adolfo Ferrando Publications

Biography
Research Summary
Publications
Lab Members

Recent Publications

  1. Wendorff AA, Quinn SA, Rashkovan M, Madubata CJ, Ambesi-Impiombato A, Litzow MR, Tallman MS, Paietta E, Paganin M, Basso G, Gastier-Foster JM, Loh ML, Rabadan R, Van Vlierberghe P, Ferrando AA. Phf6 loss enhances HSC self-renewal driving tumor initiation and leukemia stem cell activity in T-ALL. Cancer Discov. 2018 Dec 19. pii: CD-18-1005. doi: 10.1158/2159-8290.CD-18-1005.
  2. Kourtis N, Lazaris C, Hockemeyer K, Balandrán JC, Jimenez AR, Mullenders J, Gong Y, Trimarchi T, Bhatt K, Hu H, Shrestha L, Ambesi-Impiombato A, Kelliher M, Paietta E, Chiosis G, Guzman ML, Ferrando AA, Tsirigos A, Aifantis I. Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia. Nat Med. 2018 Aug;24(8):1157-1166. doi: 10.1038/s41591-018-0105-8.
  3. Dieck CL, Tzoneva G, Forouhar F, Carpenter Z, Ambesi-Impiombato A, Sánchez-Martín M, Kirschner-Schwabe R, Lew S, Seetharaman J, Tong L, Ferrando AA. Structure and mechanisms of NT5C2 mutations driving thiopurine resistance in relapsed lymphoblastic leukemia. Cancer Cell, 2018 Jul 9;34(1):136-147.
  4. Tzoneva G, Dieck CL, Oshima K, Ambesi-Impiombato A, Sánchez-Martín M, Madubata CJ, Khiabanian H, Yu J, Waanders E, Iacobucci I, Sulis ML, Kato M, Koh K, Paganin M, Basso G, Gastier-Foster JM, Loh ML, Kirschner-Schwabe R, Mullighan CG, Rabadan R, Ferrando AA. Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia. Nature. 2018; 553(7689):511-514.
  5. Palomero T, Ferrando A. Targeted cellular immunotherapy for T cell malignancies. Nat Med. 2017; 23(12):1402-1403.
  6. Ferrando AA, López-Otín C. Clonal evolution in leukemia. Nat Med. 2017; 23(10):1135-1145.
  7. Sanchez-Martin M, Ambesi-Impiombato A, Qin Y, Herranz D, Bansal M, Girardi T, Paietta E, Tallman MS, Rowe JM, De Keersmaecker K, Califano A, Ferrando AA. Synergistic antileukemic therapies in NOTCH1-induced T-ALL. Proc Natl Acad Sci U S A. 2017;114(8):2006-2011
  8. Sanchez-Martin M, Ferrando A. The NOTCH1-MYC highway toward T-cell acute lymphoblastic leukemia. Blood. 2017; 129(9):1124-1133.
  9. Oshima K, Khiabanian H, da Silva-Almeida AC, Tzoneva G, Abate F, Ambesi-Impiombato A, Sanchez-Martin M, Carpenter Z, Penson A, Perez-Garcia A, Eckert C, Nicolas C, Balbin M, Sulis ML, Kato M, Koh K, Paganin M, Basso G, Gastier-Foster JM, Devidas M, Loh ML, Kirschner-Schwabe R, Palomero T, Rabadan R, Ferrando AA. Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2016; 113(40):11306-11311.
  10. Belver L, Ferrando A. The genetics and mechanisms of T cell acute lymphoblastic leukaemia. Nat Rev Cancer. 2016; Jul 25;16(8):494-507.
  11. da Silva Almeida AC, Abate F, Khiabanian H, Martinez-Escala E, Guitart J, Tensen CP, Vermeer MH, Rabadan R*, Ferrando A* and Palomero T* The mutational landscape of CTCL and Sézary syndrome Nat Genet. 2015; 47:1465-1470.
  12. Herranz D, Ambesi-Impiombato A, Sudderth J, Sánchez-Martín M, Belver L, Tosello V, Xu L, Wendorff AA, Castillo M, Haydu JE, Márquez J, Matés JM, Kung AL, Rayport S, Cordon-Cardo C, DeBerardinis RJ and Ferrando AA*. Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in acute lymphoblastic leukemia. Nat Med. 2015;21:1182-9 (PMCID:PMC4598309) .
  13. Schnell SA, Ambesi-Impiombato A, Sanchez-Martin M, Belver L, Xu L, Qin Y, Kageyama R and Ferrando AA* Therapeutic targeting of HES1 transcriptional programs in T-ALL. Blood. 2015;125:2806-14. (PMCID: PMC4424629)
  14. Herranz D, Ambesi-Impiombato A, Palomero T, Schnell SA, Wendorff AA, Belver L, Xu L, Castillo-Martin M, Llobet-Navás D, Cordon Cardo C, Clappier E,  Soulier J and  Ferrando AA* A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia. Nat Med. 2014;20:1130-7. (PMCID: PMC4192073)
  15. Palomero T*, Couronné L, Khiabanian H, Kim M, Ambesi-Impiombato A, Perez-Garcia A, Carpenter Z, Abate F, Allegretta M, Haydu JE, Jiang X, Lossos IS, Nicolas, Balbin, Bastard, Bhagat, Piris MA, Campo E, Bernard O, Raul Rabadan R* and Ferrando AA* Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas Nat Genet.  2014;46:166-70.(PMCID:PMC3963408)
  16. Piovan E, Yu J, Tosello V, Herranz D, Ambesi-Impiombato A, Da Silva AC, Perez-Garcia A, Rigo I, Castillo M, Indraccolo S, Paietta E, Racevskis J, Rowe JM, Tallman MS, Basso G, Meijerink JP, Cordon-Cardo C, Califano A and Ferrando AA* Direct reversal of glucocorticoid resistance by AKT inhibition in T-ALL. Cancer Cell. 2013; 24: 766–776. (PMCID:PMC3878658)
  17. Perez-Garcia A, Ambesi-Impiombato A, Hadler M, Rigo I, LeDuc CA, Kelly K, Jalas C, Paietta E, Racevskis J, Rowe JM, Tallman MS, Paganin M, Basso G, Tong W, Chung WK and Ferrando AA*. Genetic loss of SH2B3 in acute lymphoblastic leukemia. Blood. 2013;122:2425-2432.(PMCID:PMC3790510)
  18. Van Vlierberghe P, Ambesi-Impiombato A, De Keersmaecker K, Hadler M, Paietta E, Tallman MS, Rowe JM, Forne C, Rue M, and Ferrando AA* Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia Blood. 2013;122:74-82.(PMCID:PMC3701905)
  19. Tzoneva G, Perez-Garcia A, Carpenter Z, Khiabanian H, Tosello V, Allegretta M, Paietta E, Racevskis J, Rowe JM, Tallman MS, Paganin M, Basso G, Hof J, Kirschner-Schwabe R, Palomero T, Rabadan R and Ferrando A* Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL Nat Med. 2013;19:368-71.(PMCID:PMC3594483)
  20. Della Gatta G, Palomero T, Perez-Garcia A, Ambesi-Impiombato A, Bansal M, Carpenter ZW, De Keersmaecker K, Sole X, Xu L, Paietta E, Racevskis J, Wiernik PH, Rowe JM, Meijerink JP, Califano A and Ferrando AA* Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL. Nat Med. 2012; 18:436-40.(PMCID:PMC3298036)
  21. Ntziachristos, P, Tsirigos* A, Van Vlierberghe P., Nedjic J, Trimarchi T, Flaherty MS, Ferres-Marco D, da Ros V, Tang Z, Siegle J, Asp P, Hadler M, Rigo I, De Keersmaecker K, Patel J, Huynh T, Utro F, Poglio S, Samon JB, Paietta E, Racevskis J,   Rowe JM, Rabadan R, Levine RL, Brown S, Pflumio F, Dominguez M, Ferrando A*, Aifantis I* Genetic inactivation of the Polycomb complex PRC2  in T cell acute lymphoblastic leukemia Nat Med. 2012; 18:298-303.(PMCID:PMC3274628)
  22. Van Vlierberghe P, Ambesi-Impiombato A, Perez-Garcia A, Haydu JE, Rigo I, Hadler M, Tosello V, Della Gatta G, Paietta E, Racevskis J, Luger SM, Rowe JM, Rue M and Ferrando AA* ETV6 mutations in early immature human T-cell leukemias. J Exp Med. 2011; 208:2571-9.(PMCID:PMC3244026)
  23. Van Vlierberghe P, Patel J, Abdel-Wahab O, Lobry C, Hedvat CV, Balbin M, Nicolas C, Payer AR, Fernandez HF, Tallman MS, Paietta E, Melnick A, Vandenberghe P, Speleman F, Aifantis I, Cools J, Levine R, Ferrando A*. PHF6 mutations in adult acute myeloid leukemia. Leukemia. 2011; 25:130-4. (PMCID:PMC3878659)
  24. Keersmaecker K, Real P, Della Gatta G, Palomero T, Sulis ML, Tosello V, Van    Vlierberghe P, Barnes K, Castillo M, Sole X, Hadler M, Lenz J, Aplan P, Kelliher M, Kee B, Pandolfi PP, Kappes D, Gounari F, Petrie H, van der Meulen J,  Speleman F, Paietta E, Racevskis J, Wiernik PH, Rowe JM, Soulier J, Avran E, Cavé H, Dastugue N, Raimondi S, Meijerink J, Cordon-Cardo C, Califano A, Ferrando AA* The TLX1 oncogene drives aneuploidy in T-cell transformation Nat Med. 2010; 16:1321-7. (PMCID:PMC2974790)
  25. Van Vlierberghe P, Palomero T, Khiabanian H, Van der Meulen J, Castillo M, Van Roy N, De Moerloose B, Philippé J, González-García S, Toribio ML, Taghon T, Zuurbier L, Cauwelier B, Harrison CJ, Schwab C, Pisecker M, Strehl S, Langerak AW, Gecz J, Sonneveld E, Pieters R, Paietta E, Rowe JM, Wiernik P, Benoit Y, Soulier J, Poppe B, Yao X, Cordon-Cardo C, Meijerink J, Rabadan R, Speleman F, Ferrando AA* PHF6 mutations in T-cell acute lymphoblastic leukemia Nat Genet. 2010;42:338-42 (PMCID: PMC2847364)
  26. Tosello V, Mansour MR, Barnes K, Paganin M, Sulis ML, Jenkinson S, Allen CG, Gale RE, Linch DC, Palomero T, Real P, Murty V, Yao X, Richards SM, Goldstone A, Rowe J, Basso G, Wiernik PH, Paietta E, Pieters R, Horstmann M, Meijerink JP, Ferrando A*. WT1 mutations in T-ALL. Blood. 2009; 114:1038-1045 (PMCID:PMC2721784)
  27. Real P, Tosello V, Palomero T, Castillo M, Hernando E, Stanchina E, Sulis ML, Barnes K, Sawai K,  Homminga I, Meijerink J, Aifantis I, Basso G, Cordon-Cardo C, Ai W and Ferrando A*. Gamma-secretase inhibitors reverse glucocorticoid resistance in T-ALL. Nat Med.  2009; 15:50-8. (PMCID:PMC2692090)
  28. Sulis ML, Williams O, Palomero T, Tosello V, Pallikuppam S, Real PJ, Barnes K, Zuurbier L, Meijerink J and Ferrando A* NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL Blood. 2008;112:733-40. (PMCID:PMC2481531)
  29. Palomero T, Sulis ML, Cortina M, Real PJ, Barnes K, Ciofani M, Caparros E, Buteau J, Brown K, Perkins SL, Bhagat G, Mishra A, Basso G, Castillo M, Nagase S, Cordon-Cardo C, Parsons R, Zúñiga-Pflücker JC, Dominguez M and Ferrando A*. Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia Nat Med. 2007;13:1203-10. (PMCID:PMC2600418)
  30. Palomero T, Lim WK, Odom D, Sulis ML, Real PJ, Margolin A, Barnes KC, O’Neil J, Neuberg D, Weng AP, Aster JC, Sigaux F, Soulier J, Look AT, Young RA, Califano A, Ferrando A*. NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc Natl Acad Sci U S A. 2006;103:18261-6.( PMCID:PMC1838740)