Dr. Richard Baer Publications

Research Summary
Lab Members

Selected Peer-Reviewed Publications

32. Chen, Q., Cheng, J.-T., Tsai, L.-H., Schneider, N., Buchanan, G., Carroll, A., Crist, W., Ozanne, B., Siciliano, M.J., and Baer, R.  (1990) The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.  EMBO J.  9: 415-424.

33. Brown, L., Cheng, J.-T., Chen, Q., Siciliano, M.J., Crist, W., Buchanan, G., and Baer, R.  (1990) Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia.  EMBO J.  9: 3343-3351.

37. Xia, Y., Brown, L., Yang, C.Y.-C., Tsan, J.T., Siciliano, M.J., Espinosa III, R., Le Beau, M.M. and Baer, R.  (1991) TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T cell leukemia.  Proc. Natl. Acad. Sci. USA  88: 11416-11420.

51. Wadman, I., Li, J., Bash, R.O., Forster, A., Osada, H., Rabbitts, T.H., and Baer, R.  (1994) Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia.  EMBO J.  13: 4831-4839.

57. Hwang, L.-Y. and Baer, R.  (1995) The role of chromosome translocations in T cell acute leukemia.  Curr. Opin. Immunol. 7: 659-664.

61. Wu, L.C., Wang, Z.W., Tsan, J.T., Spillman, M.A., Phung, A., Xu, X.L., Yang, M.-C.W., Hwang, L.-Y., Bowcock, A.M., and Baer, R.  (1996) Identification of a RING protein that can interact in vivo with the BRCA1 gene product.  Nature Genetics 14: 430-440. PMID: 8944023

69. Yu, X., Wu, L.C., Bowcock, A.M., Aronheim, A., and Baer, R. (1998) The carboxy-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression.  J. Biol. Chem. 273: 25388-25392. PMID: 9738006

72. Yu, X. and Baer, R.  (2000) Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor.  J. Biol. Chem. 275: 18541-18549. PMID: 10764811

76. Wu-Baer, F. and Baer, R. (2001) Effect of DNA damage on a BRCA1 complex.  Nature 414: 36.  PMID: 11689934

82. Wu-Baer, F., Lagrazon, K., Yuan, W., and Baer, R.  (2003) The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin.  J. Biol. Chem. 278: 34743-34746. PMID: 12890688

86. Choudhury, A.D., Xu, H., Modi, A.P., Zhang, W., Ludwig, T., and Baer, R., (2005) Hyperphosphorylation of the BARD1 tumor suppressor in mitotic cells.  J. Biol. Chem. 280: 24669-24679. PMID: 15855157

87. Yu, X., Fu, S., Lai, M., Baer, R., and Chen, J. (2006) BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP.  Genes & Dev. 20: 1721-1726. PMCID: PMC1522068

92. Laufer, M., Nandula, S.V., Modi, A.P., Wang, S., Jasin, M., Murty, V.V., Ludwig, T., and Baer, R. (2007) Structural requirements for the BARD1 tumor suppressor in chromosomal stability and homology-directed DNA repair. J. Biol. Chem. 282: 34325-34333.  PMID: 17848578

93. Sartori, A.A., Lukas, C., Coates, J., Fu, S., Baer, R., Lukas, J., and Jackson, S.P. (2007) CtIP cooperates with the MRE11 complex to promote DNA end resection.  Nature 450: 509-514. PMCID: PMC2409435

94. Dupré, A., Boyer-Chatenet, L., Sattler, R.S., Modi, A.P., Lee J.-H., Nicolette M.L., Kopelovich, L., Jasin, M., Baer, R., Paull, T.T., and Gautier, J. (2007) Identification and characterization of an inhibitor of the MRE11-RAD50-NBS1 complex.  Nature Chemical Biology 4: 119-125. PMCID: PMC3065498

95. Shakya, R., Szabolcs, M., McCarthy, E.E., Ospina, E., Basso, K., Nandula, S.V., Murty, V.V., Baer, R., and Ludwig, T. (2008) A common basal-like phenotype for mammary carcinomas induced by conditional inactivation of the BARD1 and BRCA1 tumor suppressors.  Proc. Natl. Acad. Sci. USA 105: 7040-7045. PMCID: PMC2365565

96. Reid, L.J., Shakya, R., Modi, A.P., Lokshin, M., Cheng, J.-T., Jasin, M., Baer, R., and Ludwig, T. (2008) The E3 ubiquitin ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks.  Proc. Natl. Acad. Sci. 105: 20876–20881.  PMCID: PMC2603436

97. Wu-Baer, F., Ludwig, T., and Baer, R.  (2010) The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function.  Mol. Cell. Biol. 30: 2787-2798.  PMCID: PMC2876507

98. Peterson, S.E., Li, Y., Chait, B.T., Gottesman, M.E., Baer, R., and Gautier, J. (2011) Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair.  J. Cell Biol. 194: 705-720. PMCID: PMC3171114

99. Shakya, R., Reid, L.J., Reczek, C.R., Cole, F., Egli, D., Lin, C.-S., deRooij, D.G., Hirsch, S., Ravi, K., Hicks, J.B., Szabolcs, M., Jasin, M., Baer, R., and Ludwig, T. (2011) BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity.  Science 334: 525-528.

100. Li T, Kon N, Jiang L, Tan M, Ludwig T, ZHao Y, Baer R, Gu W. (2012) Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell, 146:1269-83.

101. Peterson SE, Li Y, Wu-Baer F, Chait BT, Baer R, Yan H, Gottesman ME, Gautier J. (2013) Activation of DSB processing requires phosphorylation of CtIP by ATR. Mol. Cell, 49:657-67.

102. Baer R. (2013) Luring BRCA1 to the scene of the crime. Cancer Cell, 23:565-7.

103. Reczek CR, Szabolcs M, Start JM, Ludwig T, Baer R. (2013) The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression. J. Cell Biol. 201:693-707.

104. Aparicio T, Baer R, Gautier J. DNA double-strand break repair pathway choice and cancerDNA Repair (Amst). 2014 Apr 16. pii: S1568-7864(14)00085-8.

105. Jiang L, Kon N, Li T, Wang SJ, Su T, Hibshoosh H, Baer R, Gu W. (2015) Ferroptosis as a p53-mediated activity during tumour suppression. Nature 520(7545)57-62 PMID: 25799988

106. Aparicio T, Baer R, Gottesman M, Gautier J (2016) MRN, CtIP and BRCA1 mediate repair of topoisomerase II-DNA adducts. J Cell Biol 212(4):399-408 PMID: 26880199

107. Reczek CR, Shakya R, Miteva Y, Szabolcs M, Ludwig T, Baer R (2016) The DNA resection protein CtIP promotes mammary tumorigenesis. Oncotarget 7(22):32172-83 PMID: 27058754  

108. Chia G, Agudo J, Treff N, Sauer MV, Billing D, Brown BD, Baer R, Egli D (2017) Genomic instability during reprogramming by nuclear transfer is DNA replication dependent. Nat Cell Biol 19(4):282-291 PMID: 28263958

109. Chen D, Tavana O, Chu B, Erber L, Chen Y, Baer R, Gu W (2017) NRF2 is a major target of ARF in p53-independent tumor suppression. Mol Cell 68(1):224-232 PMID: 28985506