Dr. Swarnali Acharyya Publications

Research Summary
Lab Members

Selected Publications

  1. Wang G, Biswas AK, Ma W, Kandpal M, Coker C, Grandgenett PM, Hollingsworth MA, Jain R, Tanji K, Lόpez-Pintado S, Borczuk A, Hebert D, Jenkitkasemwong S, Hojyo S, Davuluri RV, Knutson MD, Fukada T, Acharyya S. Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle. Nat Med. 2018 Jun;24(6):770-781. doi: 10.1038/s41591-018-0054-2. [Link from CUIMC press newsroom]
  2. Consul N, Guo X, Coker C, Lopez-Pintado S, Hibshoosh H, Zhao B, Kalinsky K, Acharyya S. Monitoring Metastasis and Cachexia in a Patient with Breast Cancer: A Case Study. Clin Med Insights Oncol. 2016 Sep 11;10:83-94.
  3. Shiono M, Huang K, Downey RJ, Consul N, Villanueva N, Beck K, Fenn K, Dietz D, Yamaguchi T, Kato S, Divgi C, Kalinsky K, Wei Y, Zhang Y, Borczuk AC, Inoue A, Halmos B, Acharyya S. An analysis of the relationship between metastases and cachexia in lung cancer patients.  Cancer Med. 2016 Aug 3. doi: 10.1002/cam4.841.
  4. Acharyya S, Massague J.  Arresting supporters: targeting neutrophils in metastasis.  Cell Res. 2016 Mar;26(3):273-4. doi: 10.1038/cr.2016.17.
  5. Acharyya S, Oskarsson T, Vanharanta S, Malladi S, Kim J, Morris PG, Manova-Todorova K, Leversha M, Hogg N, Seshan VE, Norton L, Brogi E and Massague J, A CXCL1 paracrine network links cancer chemoresistance and metastasis. Cell, 150(1), 165-178(2012). PMID 22770218
  6. Oskarsson T, Acharyya S, Zhang XHF, Vanharanta S, Tavazoie SF, Morris PG, Downey RJ, Manova-Todorova K, Brogi E and Massague J. Breast cancer cells produce tenascin-C as a metastatic niche component to colonize the lungs. Nature Medicine, 17, 867-74 (2011). PMID 21706029
  7. Acharyya S, Sharma SM, Cheng A, Ladner KJ, Wang H, He W, Ostrowski M, Huang TMH, Guttridge DC. TNF inhibits Notch-1 in skeletal muscle by Ezh2 and DNA methylation mediated repression: implications in Duchenne muscular dystrophy. PLoS One 5(8): e12479 (2010). PMID 20814569
  8. Kim MY, Oskarsson T, Acharyya S, Nguyen DX, Zhang XH, Norton L and Massague J. Tumor self-seeding by circulating cancer cells. Cell, 24: 139(7):1315-26 (2009) PMID 20064377
  9. Damrauer J*, Stadler ME*, Acharyya S*, Baldwin AS, Couch ME and Guttridge DC. Chemotherapy-induced muscle wasting: association with NF-kB and cancer cachexia. Basic Applied Myology. 18(5):139-148 (2008) *Contributed equally.
  10. Gupta GP, Perk J, Acharyya S, de Candia P, Mittal V, Todorova-Manova K, Gerald WL, Brogi E, Benezra R and Massagué J. ID genes mediate tumor re-initiation during breast cancer metastasis. PNAS 104(49):19506-11 (2007) PMID 18048329
  11. Acharyya S and Guttridge DC. Cancer Cachexia Signaling pathways continue to emerge yet much still points to the proteasome. Clin Cancer Res. Mar 1;13(5):1356-61. (2007). PMID 17332276
  12. Acharyya S, Villalta SA, Bakkar N, Bupha-Intr T, Janssen PML, Carathers M, Karin M, Li ZW, Beg A, Ghosh S, Sahenk Z, Weinstein M, Gardner KL, Rafael-Fortney JA, Tidball JG, Baldwin AS and Guttridge DC. IKK/NF-kB Signaling Interplay in Macrophages and Myofibers Promotes Muscle Wasting in Duchenne Muscular Dystrophy. J Clin Invest, 117(4): 889-901. (2007). PMID 17380205
  13. Acharyya S, Butchbach ME, Sahenk Z, Wang H, Saji M, Carathers M, Ringel MD, Skipworth RJ, Fearon KC, Hollingsworth MA, Muscarella P, Burghes AH, Rafael-Fortney JA, Guttridge DC. Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia. Cancer Cell, 8(5): 421-32 (2005). PMID 16286249
  14. Acharyya S, Ladner KJ, Nelsen LL, Damrauer J, Reiser PJ, Swoap S and Guttridge DC. Cancer cachexia is regulated by selective targeting of skeletal muscle gene products. J Clin Invest, 114(3): 370-8 (2004). PMID 15286803