Dr. Wei Gu Publications

Research Summary
Lab Members


A Partial List (40 out of total 155 papers)

  1. Luo, J, Su, F., Chen, D., Shiloh, A., and Gu, W. (2000) Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature 408, 377-381.
  2. Guo, A., Salomoni, P., Luo, J., Shih, A., Zhong, S., Gu, W., and Pandolfi, P.P. (2000) Role of PML in p53-dependent apoptosis. Nature Cell Biol. 2, 730-736.
  3. Luo, J., Nikolaev, A. Y., Imai, S., Chen, D., Su, F., Shiloh, A., Guarente, L., and Gu, W. (2001) Negative control of p53 by Sir2a promotes cell survival under stress. Cell. 107, 137-148.
  4. Li, M., Chen, D., Shiloh, A., Luo, J., Nikolaev, A. Y., Qin, J., and Gu. W. (2002). Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature 416, 648-653.
  5. Hu, M., Li, P., Li, M., Li., W., Yao, T., Wu, J-W., Gu, W., Cohen, R. E., and Shi, Y. (2002) Crystal structure of a UBP-family deubiquiting enzyme: in isolation and in complex with ubiquitin aldehyde Cell 111, 1041-1054.
  6. Nikolaev, A. Y., Li, M., Puskas, N., Qin, J., and Gu, W. (2003). Parc: a cytoplasmic anchor for p53. Cell 112, 29-40.
  7. Li, M., Brooks, C, Wu-Baer, F., Chen, D., Baer, R., and Gu, W. (2003). Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science 302, 1972-5.
  8. Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W, Bultsma Y, McBurney M, Guarente L. (2004) Mammalian SIRT1 represses forkhead transcription factors. Cell, 116, 551-63.
  9. Li M, Brooks CL, Kon N, and Gu, W. (2004). A Dynamic Role of HAUSP in the p53-Mdm2 Pathway.  Mol. Cell, 13, 879-86.
  10. Kitamura YI, Kitamura T, Kruse JP, Raum JC, Stein R, Gu W, Accili D. (2005) FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab. 2, 3-63.
  11. Chen, D., Kon, N., Li, M., Zhang, W., Qin, J., and Gu, W. (2005) ARF-BP1 is a critical mediator of the ARF tumor suppressor. Cell. 121,1071-83.
  12. Chen WY, Wang DH, Yen RC, Luo J, Gu W, Baylin SB. (2005) Tumor Suppressor HIC1 Directly Regulates SIRT1 to Modulate p53-Dependent DNA-Damage Responses. Cell. 123, 437-48.
  13. Brooks, C. L. and Gu, W. (2006)  p53 ubiquitination: Mdm2 and beyond. Mol. Cell 21, 307-315.
  14. Wang C, Chen L, Hou X, Li Z, Kabra N, Ma Y, Nemoto S, Finkel T, Gu W, Cress WD, Chen J. Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol. 8,1025-31.
  15. Tang, Y., Luo, J., Zhang, W., and Gu, W. (2006) Tip60-dependent acetylation of p53 modulates the decision between cell cycle arrest and apoptosis. Mol. Cell 24, 827-839.
  16. Domingue-Sola, D., Ying, C., Li, M., Gu, W., Gautier, J. and Dalla-Favera, R. (2007) Non-transcriptional control of DNA replication by C-Myc. Nature. 448, 445-451.
  17. Zhao, W., Kruse, JP, Tang, Y., Jung, S., Qin, J., and Gu, W. (2008) Negative Regulation of the Sirt1 deacetylase by DBC1. Nature 451, 587-590.
  18. Kruse, J.P. and Gu, W. (2008) Snapshot: p53 post-translational modifications. Cell 133, 930.
  19. Tang, Y., Zhao, W., Chen, Y., Zhao, Y., and Gu, W. (2008) Acetylation is indispensible for p53 activation. Cell  133, 612-626.
  20. Banks AS, Kon N, Knight C, Matsumoto M, Gutiérrez-Juárez R, Rossetti L, Gu W, Accili D. SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab.  8, 333-41. (Gu listed as a co-corresponding author).
  21. Brooks, C. and Gu, W. (2009) How does SIRT1 affect metabolism, senescence and cancer? Nature Rev. Cancer, 9, 123-128.
  22. Kruse JP, Gu W.  (2009) Modes of p53 regulation Cell.  137, 609-622.
  23. Shan, J., Zhao, W., and Gu, W. (2009) Suppression of Cancer Cell Growth by Promoting Cyclin D1 Degradation.  Mol Cell, 36, 469-476.
  24. Chen, D., Shan, J., Zhu, W., Qin, J. and Gu, W. (2010) Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses. Nature. 464, 624-627.
  25. Charvet C, Wissler M, Brauns-Schubert P, Wang SJ, Tang Y, Sigloch FC, Mellert H, Brandenburg M, Lindner SE, Breit B, Green DR, McMahon SB, Borner C, Gu W, Maurer U. (2011) Phosphorylation of Tip60 by GSK-3 Determines the Induction of PUMA and Apoptosis by p53.   Mol Cell. 42, 584-96. PMID: 21658600
  26. Qiang,L., Hua V. Lin, Ja Young Kim-Muller, Carrie L. Welch, Gu W, and Domenico Accili (2011)  Proatherogenic Abnormalities of Lipid Metabolism in SirT1 Transgenic Mice Are Mediated through Creb Deacetylation, Cell Metab. 14, 758-67. 
  27. Li M, Gu W. (2011) A Critical Role for Noncoding 5S rRNA in Regulating Mdmx Stability. Mol Cell, 43, 1023-32. PMID: 21925390.
  28. Qiang, L., Lin, H., Kim-Muller, J., Welch, C.L., Tabas, I., Tall, A.R. Gu, W., Accili, D. (2012) Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of PPAR. Cell, 150, 620-632. PMID: 22863012.
  29. Li T., Kon N., Jiang L., Tan M., Ludwig T., Zhao Y., Baer R., and Gu W. (2012) Tumor suppression in the absence of p53-mediated cell cycle arrest, apoptosis, and senescence. Cell, 149, 1269-1283. PMID: 22682249.
  30. Chen, D., Kon, K., Zhong J., Zhang, P., Yu, L., and Gu, W. (2013) Differential effects on ARF stability by normal vs. oncogenic levels of c-Myc expression. Mol Cell, 51-46-56.
  31. Jiang L., Kon N., Li T., Wang S., Su T, Hibshoosh H., Baer R., and Gu W(2015). Ferroptosis as a p53-mediated activity during tumor suppression. Nature . 520, 57-62.
  32. Ou Y, Wang SJ, Li D, Chu B, Gu W. (2016) Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses. Proc Natl Acad Sci U S A. 2016 Nov 1; 113(44):E6806-E6812. PMID: 27698118
  33. Wang SJ, Li D, Ou Y, Jiang L, Chen Y, Zhao Y, Gu W. (2016) Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression. Cell Rep. 2016 Oct 4;17(2):366-373. doi: 10.1016/j.celrep.2016.09.022. PMID: 27705786
  34. Wang D, Kon N, Lasso G, Jiang L, Leng W, Zhu WG, Qin J, Honig B, Gu W. (2016) Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode. Nature. 2016 Oct 6; 538(7623):118-122. doi: 10.1038/nature19759. PMID: 27626385
  35. Tavana O, Li D, Dai C, Lopez G, Banerjee D, Kon N, Chen C, Califano A, Yamashiro DJ, Sun H, Gu W. (2016) HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma. Nature Medicine 2016 Oct; 22 (10):1180-1186. doi: 10.1038/nm.4180. PMID: 27618649
  36. Wang Y, Zhang N, Zhang L, Li R, Fu W, Ma K, Li X, Wang L, Wang J, Zhang H, Gu W, Zhu WG, Zhao Y. (2016) Autophagy Regulates Chromatin Ubiquitination in DNA Damage Response through Elimination of SQSTM1/p62. Mol Cell. 2016 Jul 7;63(1):34-48. doi: 10.1016/j.molcel.2016.05.027. PMID: 27345151.
  37. Chen, D., Omid Tavana, Bo Chu, Luke Erber, Yue Chen, Richard Baer and Gu, W. (2017) NRF2 is a major target of ARF in p53-independent tumor suppression. Mol Cell   Oct 5;68(1):224-232.e4. doi: 10.1016/j.molcel.2017.09.009.
  38. Liu, T., Jaing, L., Tavana, O., and Gu, W. (2019) The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SCL7A11. Cancer Research 2019 Feb 1. pii: canres.3037.2018. doi: 10.1158/0008-5472.CAN-18-3037. [Epub ahead of print]
  39. Wang, W., Michael Green et al., (2019) “CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy” Nature (in press).
  40. Chu, B., Ning Kon, Delin Chen, Tongyuan Li, Tong Liu, Le Jiang, Shujuan Song, Omid Tavana, and Gu, W. (2019) ALOX12 is required for p53-mediated tumor suppression through a distinct ferroptosis pathway. Nature Cell Biology (in press).