Dr. Wei Gu Publications

Research Summary
Lab Members


A Partial List (25 out of total 127 papers)

  1. Luo, J, Su, F., Chen, D., Shiloh, A., and Gu, W. (2000) Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature 408, 377-381.
  2. Luo, J., Nikolaev, A. Y., Imai, S., Chen, D., Su, F., Shiloh, A., Guarente, L., and Gu, W. (2001) Negative control of p53 by Sir2a promotes cell survival under stress. Cell. 107, 137-148.
  3. Li, M., Chen, D., Shiloh, A., Luo, J., Nikolaev, A. Y., Qin, J., and Gu. W. (2002). Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature 416, 648-653.
  4. Hu, M., Li, P., Li, M., Li., W., Yao, T., Wu, J-W., Gu, W., Cohen, R. E., and Shi, Y. (2002) Crystal structure of a UBP-family deubiquiting enzyme: in isolation and in complex with ubiquitin aldehyde Cell 111, 1041-1054.
  5.  Nikolaev, A. Y., Li, M., Puskas, N., Qin, J., and Gu, W. (2003). Parc: a cytoplasmic anchor for p53. Cell 112, 29-40.
  6. Li, M., Brooks, C, Wu-Baer, F., Chen, D., Baer, R., and Gu, W. (2003). Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science 302, 1972-5.
  7. Li M, Brooks CL, Kon N, and Gu, W. (2004). A Dynamic Role of HAUSP in the p53-Mdm2 Pathway. Mol. Cell, 13, 879-86.
  8. Chen, D., Kon, N., Li, M., Zhang, W., Qin, J., and Gu, W. (2005) ARF-BP1 is a critical mediator of the ARF tumor suppressor. Cell. 121,1071-83.
  9. Chen WY, Wang DH, Yen RC, Luo J, Gu W, Baylin SB. (2005) Tumor Suppressor HIC1 Directly Regulates SIRT1 to Modulate p53-Dependent DNA-Damage Responses. Cell. 123, 437-48.
  10. Brooks, C. L. and Gu, W. (2006) p53 ubiquitination: Mdm2 and beyond. Mol. Cell 21, 307-315.
  11. Tang, Y., Luo, J., Zhang, W., and Gu, W. (2006) Tip60-dependent acetylation of p53 modulates the decision between cell cycle arrest and apoptosis. Mol. Cell 24, 827-839.
  12. Domingue-Sola, D., Ying, C., Li, M., Gu, W., Gautier, J. and Dalla-Favera, R. (2007) Non-transcriptional control of DNA replication by C-Myc. Nature. 448, 445-451.
  13. Zhao, W., Kruse, JP, Tang, Y., Jung, S., Qin, J., and Gu, W. (2008) Negative Regulation of the Sirt1 deacetylase by DBC1. Nature 451, 587-590.
  14. Kruse, J.P. and Gu, W. (2008) Snapshot: p53 post-translational modifications. Cell 133, 930.
  15. Tang, Y., Zhao, W., Chen, Y., Zhao, Y., and Gu, W. (2008) Acetylation is indispensible for p53 activation. Cell 133, 612-626.
  16. Brooks, C. and Gu, W. (2009) How does SIRT1 affect metabolism, senescence and cancer? Nature Rev. Cancer, 9, 123-128.
  17. Kruse JP, Gu W. (2009) Modes of p53 regulation Cell. 137, 609-622.
  18. Chen, D., Shan, J., Zhu, W., Qin, J. and Gu, W. (2010) Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses. Nature. 464, 624-627.
  19. Li M, Gu W. (2011) A Critical Role for Noncoding 5S rRNA in Regulating Mdmx Stability. Mol Cell, 43, 1023-32. PMID: 21925390.
  20. Qiang, L., Lin, H., Kim-Muller, J., Welch, C.L., Tabas, I., Tall, A.R. Gu, W., Accili, D. (2012) Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of PPAR. Cell, 150, 620-632. PMID: 22863012.
  21. Mungamuri SK, Benson EK, Wang S, Gu W, Lee SW, Aaronson SA. (2012) p53-mediated heterochromatin reorganization regulates its cell fate decisions. Nat Struct Mol Biol. 19, 478-84 PMID: 22466965.
  22. Li T., Kon N., Jiang L., Tan M., Ludwig T., Zhao Y., Baer R., and Gu W. (2012) Tumor suppression in the absence of p53-mediated cell cycle arrest, apoptosis, and senescence. Cell, 149, 1269-1283. PMID: 22682249.
  23. Chen, D., Kon, K., Zhong J., Zhang, P., Yu, L., and Gu, W. (2013) Differential effects on ARF stability by normal vs. oncogenic levels of c-Myc expression. Mol Cell, 51-46-56.
  24. Qiang L, Kon N, Zhao W, Jiang L, Knight CM, Welch C, Pajvani U, Gu W, Accili D. (2015) Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions. Cell Rep. 11, 1797-808.
  25. Jiang L., Kon N., Li T., Wang S., Su T, Hibshoosh H., Baer R., and Gu W(2015). Ferroptosis as a p53-mediated activity during tumor suppression. Nature . 520, 57-62.
  26. Shi D, Dai C, Qin J, Gu W. (2016) Negative regulation of the p300-p53 interplay by DDX24. Oncogene. 35(4):528-36.
  27. Li T, Liu X, Jiang L, Manfredi J, Zha S, Gu W. (2016) Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging. Oncotarget. 2016; 7(11):11838-49
  28. Tavana O, Li D, Dai C, Lopez G, Banerjee D, Kon N, Chen C, Califano A, Yamashiro DJ, Sun H, Gu W. (2016) HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma. Nat Med. 22(10):1180-1186.
  29. Wang D, Kon N, Lasso G, Jiang L, Leng W, Zhu WG, Qin J, Honig B, Gu W. (2016) Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode. Nature; 538(7623):118-122
  30. Wang SJ, Li D, Ou Y, Jiang L, Chen Y, Zhao Y, Gu W. (2016) Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression. Cell Rep.; 17(2):366-373
  31. Ou Y, Wang SJ, Li D, Chu B, Gu W. (2016)  Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses. Proc Natl Acad Sci U S A.; 113(44):E6806-E6812.
  32. Tavana O, Gu W. Modulation of the p53/MDM2 interplay by HAUSP inhibitors.  (2017) J Mol Cell Biol.; 9(1):45-52
  33. Chen D, Tavana O, Chu B, Erber L, Chen Y, Baer R, Gu W. (2017) NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression. Mol Cell; 68(1):224-232
  34. Kon N, Wang D, Li T, Jiang L, Qiang L, Gu W. (2018) Inhibition of Mdmx (Mdm4) in vivo induces anti-obesity effects. Oncotarget; 9(7):7282-7297
  35. Li D, Tavana O, Sun SC, Gu W. (2018) Peli1 modulates the subcellular localization and activity of Mdmx. Cancer Res. Mar 9. pii: canres.3531.2017. doi: 10.1158/0008-5472.CAN-17-3531.
  36. Tavana O, Sun H, Gu W. (2018) Targeting HAUSP in both p53 wildtype and p53-mutant tumors. Cell Cycle. May 15:1-6. doi: 10.1080/15384101.2018.1456293.
  37. Liu T, Jiang L, Tavana O, Gu W. The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SCL7A11. Cancer Res. 2019 Feb 1. pii: canres.3037.2018. doi: 10.1158/0008-5472.CAN-18-3037.
  38. Chen D, Tavana O, Gu W. ARF-NRF2: A new checkpoint for oxidative stress responses? Mol Cell Oncol. 2018 Feb 6;5(3):e1432256. doi: 10.1080/23723556.2018.1432256. eCollection 2018.