Dr. Zhiguo Zhang Publications

Biography
Research Summary
Publications
Lab Members

Publications

  1. Tatavosian R, Duc HN, Huynh TN, Fang D, Schmitt B, Shi X, Deng Y, Phiel C, Yao T, Zhang Z, Wang H, Ren X. Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation. Nat Commun. 2018 May 25;9(1):2080. doi: 10.1038/s41467-018-04455-7

  2. Serra-Cardona A, Zhang Z.  Replication-Coupled Nucleosome Assembly in the Passage of Epigenetic Information and Cell Identity.  Trends Biochem Sci. 2018 Feb;43(2):136-148

  3. Zhang H, Gan H, Wang Z, Lee JH, Ordog T, Wold M, Ljungman M and Zhang Z. RPA interacts with HIRA and regulates H3.3 deposition at gene regulatory elements in mammalian cells. Mol Cell (2017) in press

  4. Wei Li, Ping Chen, Juan Yu, Liping Dong, Dan Liang, Jianxun Feng, Jie Yan, Peng-Ye Wang, Qing Li, Zhiguo Zhang, Ming Li, Guohong Li. FACT Remodels the Tetranucleosomal Unit of Chromatin Fibers for Gene Transcription (2016). Mol Cell, 64: 120-133.

  5. Fang D, Gan H, Lee J, Han J, Wang Z, Riester SM, Jin L, Chen J, Zhou H, Wang J, Zhang H, Yang N, Bradley EW, Ho TH, Rubin BP, Bridge JA, Thibodeau SN, Ordog T, Chen Y, van Wijnen AJ, Oliveira AM, Xu R, Westendorf JJ, Zhang Z. The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas (2016). Science, 352:1344-1348.

  6. Lee J and Zhang Z. O-linked N-acetyglucosamine transferase (OGT) interacts with HIRA complex and regulates nucleosome assembly and cellular senescence (2016) PNAS, 113:E3213-E3220.

  7. Wang Z, Liu J, Zhang H, Cheruiyot A, Lee J, Ordog T, Lou Z, You Z, Zhang Z (2016) USP51 deubiquitylates histone H2AK15ub and regulates DNA damage response. Genes and Dev, 30:946-59 (highlighted in Nature Reviews Molecular Cell Biology)

  8. Dahlin JL, Chen X, Walters MA, Zhang Z. (2015) Histone-modifying enzymes, histone modifications and histone chaperones in nucleosome assembly: Lessons learned from Rtt109 histone acetyltransferases. Crit Rev Biochem Mol Biol. 50:31-53. PMCID:4415165.

  9. Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X, Fang D, Huang X, Tom MW, Ngo V, Solomon D, Mueller S, Paris PL, Zhang Z, Petritsch C, Gupta N, Waldman TA, James CD. (2014) Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med. 20:1394-6. PMCID:4257862. (Highlighted in Nature Medicine)

  10. Yu C, Gan H, Han J, Zhou ZX, Jia S, Chabes A, Farrugia G, Ordog T, Zhang Z. (2014) Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stall. Mol Cell. 56:551-63.PMCID:436266. (Highlighted in Molecular Cell and F1000).

  11. Han J, Zhang H, Zhang H, Wang Z, Zhou H, Zhang Z. (2013) A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly. Cell. 155:817-29. PMCID:3994564.

  12. Chan KM, Fang D, Gan H, Hashizume R, Yu C, Schroeder M, Gupta N, Mueller S, James CD, Jenkins R, Sarkaria J, Zhang Z. (2013) The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression. Genes Dev. 27:985-90. PMCID:3656328. (Highlighted in Science and Nature Review Cancer)

  13. Burgess RJ, Zhang Z. (2013) Histone chaperones in nucleosome assembly and human disease. Nat Struct Mol Biol. 20:14-22. PMCID:4004355.

  14. Liu CP, Xiong C, Wang M, Yu Z, Yang N, Chen P, Zhang Z, Li G, Xu RM. (2012) Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX. Nat Struct Mol Biol. 19:1287-92. PMCID:3932182.

  15. Su D, Hu Q, Li Q, Thompson JR, Cui G, Fazly A, Davies BA, Botuyan MV, Zhang Z*, Mer G*. (2012) Structural basis for recognition of H3K56-acetylated histone H3-H4 by the chaperone Rtt106. Nature. 483:104-7. PMCID:3439842 (*co-corresponding authors).

  16. Chan KM, Zhang H, Malureanu L, van Deursen J, Zhang Z. (2011)Diverse factors are involved in maintaining X chromosome inactivation. Proc Natl Acad Sci U S A. 108:16699-704. PMCID:3189073.

  17. Kang B, Pu M, Hu G, Wen W, Dong Z, Zhao K, Stillman B, Zhang Z. (2011) Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly. Genes Dev. 25:1359-64. PMCID:3134079.

  18. Han J, Li Q, McCullough L, Kettelkamp C, Formosa T, Zhang Z. (2010) Ubiquitylation of FACT by the cullin-E3 ligase Rtt101 connects FACT to DNA replication. Genes Dev. 24:1485-90. PMCID:2904938.

  19. Burgess RJ, Zhou H, Han J, Zhang Z. (2010) A role for Gcn5 in replication-coupled nucleosome assembly. Mol Cell. 37:469-80. PMCID:2954627. (Highlighted in Molecular Cell)

  20. Falbo KB, Alabert C, Katou Y, Wu S, Han J, Wehr T, Xiao J, He X, Zhang Z, Shi Y, Shirahige K, Pasero P, Shen X. (2009) Involvement of a chromatin remodeling complex in damage tolerance during DNA replication. Nat Struct Mol Biol. 16:1167-72. PMCID:2974178.

  21. Li Q, Zhou H, Wurtele H, Davies B, Horazdovsky B, Verreault A, Zhang Z. (2008) Acetylation of histone H3 lysine 56 regulates replication-coupled nucleosome assembly. Cell. 134:244-55. PMCID:2597342. (Highlighted in Cell)

  22. Huang S, Zhou H, Tarara J, Zhang Z. (2007) A novel role for histone chaperones CAF-1 and Rtt106p in heterochromatin silencing. EMBO J. 26:2274-83. PMCID:1864969.

  23. Collins SR, Miller KM, Maas NL, Roguev A, Fillingham J, Chu CS, Schuldiner M, Gebbia M, Recht J, Shales M, Ding H, Xu H, Han J, Ingvarsdottir K, Cheng B, Andrews B, Boone C, Berger SL, Hieter P, Zhang Z, Brown GW, Ingles CJ, Emili A, Allis CD, Toczyski DP, Weissman JS, Greenblatt JF, Krogan NJ. (2007) Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature. 446:806-10.

  24. Han J, Zhou H, Horazdovsky B, Zhang K, Xu RM, Zhang Z. (2007) Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication. Science. 315:653-5. (Highlighted in Science and Nature Reviews Molecular Cell Biology).

  25. Huang S, Zhou H, Katzmann D, Hochstrasser M, Atanasova E, Zhang Z. (2005) Rtt106p is a histone chaperone involved in heterochromatin-mediated silencing. Proc Natl Acad Sci U.S.A. 102:13410-5. PMCID:1224646.

  26. Zhang Z, Shibahara K, Stillman B. (2000) PCNA connects DNA replication to epigenetic inheritance in yeast. Nature. 408:221-5.